Histopathological categorization of desmoplastic reaction in gallbladder carcinoma: its relation to cancer invasiveness and prognostic utility

Abstract Background Desmoplastic changes in a tumor have been observed to affect the microenvironment, leading both facilitation and prevention of invasiveness. Methods Between 2016 2020, total 120 patients were diagnosed with gallbladder carcinoma. The cases reviewed for type desmoplastic reaction, grade, stage. reaction was classified as mature, intermediate, immature, they correlated grade Results Out number cases, 21.67%, 48.33%, 25%, 5% belonged stages 1, 2, 3, 4, respectively. A 79.2% these showed stromal there significant correlation ( p < 0.05) between desmoplasia occurrence immature stroma increasing stage, mature negatively Conclusion assessment primary carcinoma can predict